Successful Treatment of Cryptococcal Osteomyelitis
A patient with thoracic cryptococcal osteomyelitis was treated successfully with the combination of fluconazole and flucytosine. This is the first reported case of cryptococcal osteomyelitis successfully treated with fluconazole and flucytosine.

Cryptococcus neoformans is an encapsulated yeast that usually causes pulmonary infection and meningitis in immunocompromised hosts. It is an uncommon cause of osteomyelitis, with only 41 cases reported in the literature since 1956, the year that amphotericin B became available. Treatment of this infection generally involves surgical debridement and amphotericin B with or without flucytosine. In this report, a patient with thoracic osteomyelitis and a paraspinous abscess due to C neoformans was treated with the combination of fluconazole and flucytosine. This appears to be the first reported case of cryptococcal osteomyelitis successfully treated with fluconazole with or without flucytosine.