Journey of Tinnitus: Myths, Models, Membranes and Medicines
Journey of Tinnitus: Myths, Models, Membranes and Medicines
At least two types of spontaneous activity described tinnitus in animal models—bursting activity and increased synchronicity. Both of these types are capable of triggering substantial post-synaptic responses in the central auditory system to drive tinnitus. Indeed bursting activity of the auditory nerve, dorsal cochlear nucleus and inferior colliculus was noted in animal models. Increased synchrony at auditory nerve, inferior colliculus and primary auditory cortex was also seen in animal models of tinnitus.
Electrophysiological Nature of Increased Spontaneous Activity-Bursting versus Increased Synchronicity
At least two types of spontaneous activity described tinnitus in animal models—bursting activity and increased synchronicity. Both of these types are capable of triggering substantial post-synaptic responses in the central auditory system to drive tinnitus. Indeed bursting activity of the auditory nerve, dorsal cochlear nucleus and inferior colliculus was noted in animal models. Increased synchrony at auditory nerve, inferior colliculus and primary auditory cortex was also seen in animal models of tinnitus.
