Treatment of Acute Lung Injury
Treatment of Acute Lung Injury
Anti-inflammatory therapies that have been, or are currently being, investigated include pharmaconutrients, antioxidants, antiproteases, and ketoconazole. Corticosteroids have been extensively investigated in ALI but are the subject of a separate article in this issue and will not be considered further. Current pharmacological agents (Table 1) aimed at improving respiratory physiology include diuretics and β2 agonists to minimize pulmonary edema, various agents, but primarily vasodilators and anticoagulants, to optimize alveolar perfusion, and surfactant and neuromuscular blocking agents to limit iatrogenic ventilator-associated lung injury.
Current Therapies
Anti-inflammatory therapies that have been, or are currently being, investigated include pharmaconutrients, antioxidants, antiproteases, and ketoconazole. Corticosteroids have been extensively investigated in ALI but are the subject of a separate article in this issue and will not be considered further. Current pharmacological agents (Table 1) aimed at improving respiratory physiology include diuretics and β2 agonists to minimize pulmonary edema, various agents, but primarily vasodilators and anticoagulants, to optimize alveolar perfusion, and surfactant and neuromuscular blocking agents to limit iatrogenic ventilator-associated lung injury.