Acute-on-Chronic Liver Failure
Acute-on-Chronic Liver Failure
The role of bacterial infections in the pathogenesis of ACLF could have been underestimated by the CANONIC study because the diagnosis of infections was based on routine procedures. In any case, the presence or absence or the type of precipitating event is unrelated to the severity of ACLF and the short-term mortality rate. Precipitating events, therefore, are important in the occurrence of the syndrome, but once it develops the prognosis depends on the number of organ failures. As indicated later, the severity of ACLF probably depends more on the individual response to the precipitating event.
Mortality Associated With Acute on Chronic Liver Failure Is Unrelated to the Presence or Type of Precipitating Events
The role of bacterial infections in the pathogenesis of ACLF could have been underestimated by the CANONIC study because the diagnosis of infections was based on routine procedures. In any case, the presence or absence or the type of precipitating event is unrelated to the severity of ACLF and the short-term mortality rate. Precipitating events, therefore, are important in the occurrence of the syndrome, but once it develops the prognosis depends on the number of organ failures. As indicated later, the severity of ACLF probably depends more on the individual response to the precipitating event.
