Acute Fibrinous and Organizing Pneumonia After Lung Transplant
Acute Fibrinous and Organizing Pneumonia After Lung Transplant
Immunocompromised patients, especially after lung transplantation are at high risk to develop atypical pneumonias. Among viral infections, influenza A/H1N1 pneumonia can lead to severe respiratory conditions in this patient group often resulting in deadly respiratory insufficiency. Acute fibrinous and organizing pneumonia (AFOP) is a distinct reaction pattern in acute respiratory failure with high mortality rate of upto 90%. Although some causes of AFOP are known so far, its pure form without the presence of accompanying hyaline membranes typical for diffuse alveolar damage (DAD) has not been described to be linked to viral pneumonias.
Background
Immunocompromised patients, especially after lung transplantation are at high risk to develop atypical pneumonias. Among viral infections, influenza A/H1N1 pneumonia can lead to severe respiratory conditions in this patient group often resulting in deadly respiratory insufficiency. Acute fibrinous and organizing pneumonia (AFOP) is a distinct reaction pattern in acute respiratory failure with high mortality rate of upto 90%. Although some causes of AFOP are known so far, its pure form without the presence of accompanying hyaline membranes typical for diffuse alveolar damage (DAD) has not been described to be linked to viral pneumonias.