Vitamin D and Metabolic Profile in Non-diabetic Adults
Vitamin D and Metabolic Profile in Non-diabetic Adults
Although the role of genetic factors in the metabolism of vitamin D is recognized, much remains to be understood regarding this relationship. Our results obtained from non-diabetic Afro-Caribbean individuals confirm the associations of the GC and NADSYN1 genes with vitamin D status and suggest that polymorphisms in these genes contribute to dyslipidemia and overweight independently of 25 hydroxyvitamin D levels. As vitamin D status is linked to several adverse outcomes, genetic variants associated with vitamin D levels may also play a role in the etiology of these diseases. Thus, it will be of interest to confirm these findings in other populations and ethnic groups.
Conclusions
Although the role of genetic factors in the metabolism of vitamin D is recognized, much remains to be understood regarding this relationship. Our results obtained from non-diabetic Afro-Caribbean individuals confirm the associations of the GC and NADSYN1 genes with vitamin D status and suggest that polymorphisms in these genes contribute to dyslipidemia and overweight independently of 25 hydroxyvitamin D levels. As vitamin D status is linked to several adverse outcomes, genetic variants associated with vitamin D levels may also play a role in the etiology of these diseases. Thus, it will be of interest to confirm these findings in other populations and ethnic groups.